Semaglutide 15MG

Product details

Semaglutide

CAS Number: 910463-68-2
Molecular Formula: C187H291N45O59
Molecular Weight: ~4113.58 g/mol
INN (International Nonproprietary Name): Semaglutide
Brand Names (for reference): Ozempic®, Wegovy®, Rybelsus®
Peptide Sequence: H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Nε-γGlu-C18 diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Purity: ≥98% (HPLC)
Form: White to off-white lyophilized powder
Solubility: Soluble in water and buffered aqueous solutions
Storage: Store lyophilized at −20°C; refrigerate after reconstitution at 2–8°C
Shelf Life: 24 months (under recommended storage)

🔬 Product Overview:

Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) developed to mimic the effects of endogenous GLP-1, a key incretin hormone. It is engineered with amino acid substitutions and a C18 fatty diacid side chain, which extends its half-life by enabling albumin binding, allowing for once-weekly dosing.

Semaglutide has demonstrated substantial benefits in glycemic control, appetite suppression, and weight loss, and is used clinically for managing type 2 diabetes, obesity, and cardiometabolic conditions.

✅ Key Benefits & Research Applications:

Mimics natural GLP-1 activity, improving insulin secretion and lowering glucagon

Promotes weight loss via appetite regulation and slowed gastric emptying

Reduces HbA1c, fasting glucose, and postprandial glucose

Improves cardiovascular risk markers in obese and diabetic patients

Once-weekly administration improves adherence (via extended half-life)

Studied for potential applications in NASH, PCOS, and neuroprotection

⚙️ Mechanism of Action:

Semaglutide activates the GLP-1 receptor, resulting in:

Increased insulin secretion in response to high glucose levels

Suppression of glucagon release from alpha cells

Delayed gastric emptying, reducing appetite and caloric intake

Enhanced satiety through central nervous system pathways

Improved beta-cell function and reduced insulin resistance

Its C18 fatty acid side chain enables reversible binding to albumin, significantly prolonging plasma half-life to approximately 165 hours.